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JCU 2010 December;18(4) :134-138.
doi:https://doi.org/10.4250/jcu.2010.18.4.134
Urine Albumin Creatinine Ratio is Associated with Carotid Atherosclerosis in a Community Based Cohort: Atherosclerosis Risk of Rural Area in Korean General Population Study
Joong Kyung Sung, Jang-Young Kim, Young Jin Youn, Jun Won Lee, Sung Gyun Ahn, Byung Su Yoo, Seung Hwan Lee, Junghan Yoon, Kyung-Hoon Choe, Jin Ha Yoon, Jong Ku Park, Sang Baek Koh.
1Devision of Cardiology, Department of Internal Medicine, 2Department of Preventive Medicine and Institute of Occupational Medicine, 3Institute of Genomic Cohort,Yonsei University Wonju College of Medicine, Wonju, Korea.
Corresponding Author: Jang-Young Kim ,
ABSTRACT
Background:
Albuminuria is a surrogate marker of endothelial dysfunction and a predictor of cardiovascular events. Data are limited with regard to the relationship between albuminuria and subclinical atherosclerosis in a community-based cohort. We determined the association between albuminuria measured by the urine albumin creatinine ratio (UACR) and carotid intima media thickness (CIMT) in a Korean rural population.
Methods:
We enrolled 1,369 healthy subjects older than 40 years (857 males and 518 females) with normal renal function and measured the CIMT. We excluded subjects with overt proteinuria (> 300 mg/day) or with treatment of diabetes mellitus, hypertension, dyslipidemia, and any cardiovascular disease. The subjects were stratified into the quartile value of the UACR (lowest quartile: UACR < 4.8 and highest quartile: UACR > 17.7). And we evaluate the relationship between UACR and CIMT by linear regression and logistic regression analysis.
Results:
Increasing quartile of the UACR had a stepwise increase in body mass index, blood pressure, cholesterol profile [low density lipoprotein (LDL)-cholesterol and triglyceride], glucose, homeostratic model assessment of insulin resistance (HOMA-IR), and C-reactive protein (all p values < 0.001). Maximal CIMT from the 1st to the 4th quartile values of the UACR were 0.74 ± 0.17, 0.77 ± 0.18, 0.78 ± 0.18, and 0.82 ± 0.21 mm, respectively (p < 0.001). In a multivariate regression model adjusted for age, sex, systolic blood pressure, triglyceride, LDL-cholesterol, fasting blood sugar, waist circumference, adiponectin, HOMA-IR, high sensitive C-reactive protein, smoking, UACR showed a significant association with maximal CIMT (B = 0.014, R2 = 0.145, p = 0.002).
Conclusion:
Albuminuria measured by the UACR was significantly associated with both CIMT and traditional risk factors of atherosclerosis except for smoking in healthy Koreans.
Keywords: Urine albumin creatinine ratio, Carotid intima-media thickness.
Volume 25, No 1
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