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JCU 2006 ;14(1) :12-18.
A Comparison of Tissue Doppler Echocardiography and B-Type Natriuretic Peptide in Estimating Pulmonary Capillary Wedge Pressure
Woo-Hyung Bae, Hyeon-Gook Lee, Jun-Hyok Oh, Dong-Won Lee, Byung-Jae Ahn, Seong-Ho Kim, Joon-Sang Lee, Moo-Young Kim, Yun-Seong Kim, Han-Cheol Lee, Jun Kim, June-Hong Kim, Kook-Jin Chun, Taek-Jong Hong, Yung-Woo Shin
Department of Internal Medicine, College of Medicine, Pusan National University, Busan, Korea
Corresponding Author: Yung-Woo Shin ,
Background : There are several echocardiographic parameters, such as early transmitral velocity/tissue Doppler mitral annular early diastolic velocity (E/Ea) or deceleration time, reported to be reliable indices to estimate pulmonary capillary wedge pressure (PCWP). Recently, B-type natriuretic peptide (BNP) level is also reported to increase in accordance with increased left ventricular filling pressure in systolic or diastolic heart failure. This study was performed to compare E/Ea and BNP for the ability to estimate PCWP. Methods : Several echocardiographic Doppler parameters including especially E/Ea were obtained from transthoracic Doppler echocardiography. Simultaneously, serum BNP level and PCWP estimated by using Swan-Ganz catheter were obtained, respectively. Results : E/Ea revealed a correlation of r=0.88 (p<0.001) with PCWP compared with r=0.45 (p<0.001) between BNP and PCWP. E/Ea ≥11 was the optimal cutoff to predict PCWP ≥15 mmHg (sensitivity, 94%; specificity, 90%), whereas the optimal BNP cutoff was ≥250 pg/mL (sensitivity, 52%; specificity, 74%). Conclusion : Mitral E/Ea has a better correlation with PCWP than BNP. Mitral E/Ea appears more sensitive and specific than BNP for PCWP ≥15 mmHg in cardiac patients.
Keywords: E/Ea, B-type natriuretic peptide, Pulmonary capillary wedge pressure, Echocardiography
Volume 25, No 1
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