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Evaluation of cardiac functions in children and adolescents with type I diabetes
Faten AbdelAziz, Shereen Abd-El Ghaffar , Eman Hussein, Aya M Fattouh*
Cairo university pediatrics
Corresponding Author: Aya M Fattouh ,Email: aya.fattouh@gmail.com
ABSTRACT
Background:
Cardiac dysfunction in patients with type1 Diabetes (T1DM) represents one of the serious complications. Objective: To evaluate the cardiac function in children with T1DM by conventional echocardiography and tissue Doppler imaging (TDI).
Methods:
the study included 40 T1DM patients (age between 6 and 16 years) with more than 5 years duration of diabetes and 42 healthy control children. The patients were subjected to clinical evaluation and laboratory investigations (Glycosylated hemoglobin A1C, serum lipids and lipoproteins). Conventional echocardiography and TDI were performed to patients and controls.
Results:
The patients had lower early diastolic filling velocity (E wave) of the tricuspid valve and mitral valves with a P-value of (0.000 and 0.006 respectively). Using TDI revealed that patients had lower S´velocity of the RV and LV, shorter IVCT, longer IVRT and lower E/E´ of the RV than controls (p value 0.002, 0.001, 0.004, 0.003& 0.016 respectively). The MPI of the LV of the patients was significantly higher than controls (p value 0.02). Twenty eight patients had poor glycemic control without significant differences between them and those with good glycemic control regarding echocardiographic data. Patients with dyslipidemia (13 patients) had higher late diastolic filling velocity of the mitral valve (A) and the lower LV late tissue velocity (A ′) (p wave 0.047& 0.015). No correlation existed between the duration or HbA1c and the echocardiographic parameters.
Conclusion:
Diabetic children have evidence of diastolic dysfunctions. Periodic cardiac evaluation with both conventional and tissue Doppler echocardiography is recommended for early detection of this dysfunction.
Keywords: Tissue Doppler echocardiography , Type I diabetes, Children, Diabetic cardiomyopathy
Volume 25, No 3
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